Retatrutide may support weight loss by:

• reducing appetite

• increasing feelings of fullness

• slowing digestion

• increasing energy expenditure

• improving fat breakdown

• reducing fat storage

This combination of effects has made retatrutide a promising potential treatment for obesity and metabolic disease. Retatrutide is an investigational weight loss medicine that works by targeting three hunger-regulating hormone receptors, GIP, GLP-1, and glucagon simultaneously, which is why it is often called a "triple agonist " or triple G’.

Unlike existing weight loss medications that target one or two hormones, retatrutide activates three hormone receptors:

• GIP (glucose-dependent insulinotropic polypeptide receptor) - an incretin hormone released after eating that stimulates insulin secretion

• GLP-1 (glucagon-like peptide-1 receptor) - a second incretin hormone that also stimulates insulin release

• GCG (glucagon receptor) - a hormone secreted by the pancreas that regulates glucose production in the liver.

How Does Retatrutide Compare to Zepbound and Wegovy?

All three medicines work by targeting hormones that regulate hunger and blood sugar, but they differ in how many hormones they target - and the clinical trial results suggest that more targets may mean more weight loss.

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Key takeaways:

• Wegovy targets one hormone, GLP-1, and is the most established obesity medication in this class, with the longest real-world track record

• Zepbound targets GLP-1 and a second hormone, GIP, to tackle weight loss, diabetes, and other weight-related conditions

• Retatrutide goes a step further by targeting GLP-1, GIP, and adding glucagon as a third target, with Phase 3 trial results suggesting this translates to meaningfully greater weight loss than either approved option

Retatrutide is also being studied in Phase 3 clinical trials for its effectiveness and safety in type 2 diabetes, moderate-to-severe Obstructive Sleep Apnea , knee osteoarthritis pain, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatotic liver disease. – I have noticed that my sleep has been better this week, even though my Urinary Tract issues and Prostate keep me getting up every 1-2 hours a night. But this morning I also realized that my CPAP machine reported that my incidents per hour were down to 8. They have been as high as 55 incidents per hour, so I suspect that this is helping me with my Obstructive Sleep Apnea as well.

 

Peptides After 50: Why Everyone's Talking About Them - Richard Kelley M.D. https://www.youtube.com/watch?v=gEXMYv_nq34

 

NAD is not a peptide and stands for nicotinamide adenine dinucleotide. It’s a tiny molecule found in every cell in your body. It helps keep your muscles, brain and heart healthy. Without NAD, you wouldn’t be able to turn food into energy, move your muscles or stay alive. NAD helps your cells make energy by carrying electrons from one chemical reaction to another. This process powers nearly everything your body does, and it keeps your cells working properly as you get older.

Your body makes NAD using building blocks called precursors. These include forms of vitamin B3 (like niacin) and the amino acid tryptophan. Your cells can create NAD from scratch or recycle it from smaller molecules. Enzymes — proteins that drive chemical reactions — help keep this process running. If these enzymes don’t work properly, NAD levels can drop. This can affect energy production and overall cell health.

What are the functions of nicotinamide adenine dinucleotide?

One of NAD’s most important roles is helping to convert the food you eat into usable energy. This process happens largely in the mitochondria, often called the “powerhouse” of the cell.

NAD also supports several other key functions, including:

• DNA repair: NAD helps enzymes fix damage to your genetic material.

• Metabolism: It supports chemical reactions that break down nutrients.

• Cell protection: NAD helps limit harmful byproducts that can build up when cells are under stress.

• Teamwork: It supports the normal function of your muscles, brain cells, heart cells and bones.

Healthy NAD levels address age-related changes such as:

• Muscle weakness and fatigue

• Eye conditions, like vision loss and glaucoma

• Metabolic disorders, including Type 2 diabetes and obesity

• Heart issues, like arrhythmia and heart failure

• Cognitive decline, including slower thinking and memory loss

A Note from the Cleveland Clinic

NAD is always at work in the background, helping your cells turn food into energy and respond to everyday stress. Moving your body, eating foods with the right nutrients and getting enough rest may help give your cells what they need to keep going strong. By helping NAD out, you may be able to support yourself, now and in the years ahead.